Cortical spreading depression as a target for anti-migraine agents Post date May 26, 2022 Tags antiepileptics, calcitonin gene-related peptides, calcium channels, Cortical spreading depression, current prophylactic drugs, gepants, glutamate, Ionotropic glutamate receptors, Sodium channels, tonabersat ← Vagus nerve stimulation inhibits cortical spreading depression exclusively through central mechanisms → Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets