Lab & Resources

Migraine

• Spreading depression susceptibility (KCl, electrical, optogenetic)

• Spreading depression-induced allodynia, grimace

Cerebral ischemia

• Proximal MCAO (endovascular filament)

• Distal MCAO (clip)

• ICA embolization

• Subcortical white matter lesion (L-NIO, Endothelin)

• Bilateral common carotid artery stenosis

Intracranial aneurysm formation, growth, rupture, and subarachnoid hemorrhage

• Prechiasmatic cistern blood injection

• Cisterna magna blood injection

• Endovascular puncture

• Elastase-induced intracranial aneurysms

• Hashimoto model

Intracerebral hemorrhage

• Autologous/homologous blood injection

• Collagenase-induced cortical or striatal hemorrhage

Seizures

• Focal cortical seizures

• Generalized seizures

Cerebrovascular physiology

• Cerebrovascular autoregulation

• Neurovascular coupling

• Hypercapnic/hypoxic hyperemia

Optical imaging

• Laser speckle contrast imaging

• Resting state functional connectivity imaging

• Intrinsic optical signal imaging

• Multispectral reflectance imaging

• Two-photon microscopy

Electrophysiology

• Epicranial or epidural, EEG, evoked potentials

• Intraparenchymal extracellular AC/DC field potential recordings

Non-invasive optogenetic stimulation through a chronic coverslip (Channelrhodopsin-2)

Transgenic mouse models

• CADASIL (TgNotch3R169C)

• FHM (CaV2.1 S218L or R192Q knockin)

• Tie-2 GFP

• GCaMP

Intracranial pressure measurements

Laser Doppler flowmetry

Systemic physiological monitoring

• Arterial blood pressure, heart rate, blood gas

• Mechanical ventilation

• Awake continuous body temperature

Rodent micro/neurosurgery

Microdialysis/HPLC

Normobaric hypoxia/hyperoxia chamber

Rodent neurocognitive examination

• Y-maze

• Water maze

• Open field activity and thigmotaxis

• Novel object

• Corner

• Wire grip

• Cylinder

• Elevated plus maze

• Grid walk

• Horizontal wire

• Pole

Routine molecular biology